Are Si-Quat Antimicrobial Protectants effective on SARS-CoV-2 (COVID-19)?

Question? Can Antimicrobial Protectants with the Active Ingredient 3-(trimethoxysilyl) propyldimethyloctadecyl ammonium chloride or 3-(trihydroxysilyl) propyldimethyloctadecyl ammonium chloride (aka Si-Quat) kill SARS-CoV-2 (COVID-19)?

 Answer: YES…The Environmental Protection Agency (EPA) issued an emergency declaration on August 24, 2020 to the state of Texas approving the use of a Si-Quat Antimicrobial product on airplanes, airports, and medical facilities that will kill COVID-19 for up to 7 days after the surface has been treated. EPA Administrator Andrew Wheeler told reporters “This is a groundbreaking step that is expected to provide longer-lasting protection in public spaces”.

 In other countries, longer term testing (45+ days) of a Si-Quat Antimicrobial Protectant directly on SARS-CoV-2 (COVID-19) have been completed with promising results. See edited summary below.

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TWO CENTERS OF EXCELLENCE OF THE GLOBAL VIRUS NETWORK INDEPENDENTLY VERIFY AN ANTIMICROBIAL TECHNOLOGY THAT ERADICATES SARS-COV-2 ON SURFACES FOR MORE THAN SIX WEEKS

Click Here to download the study

The Global Virus Network (GVN) demonstrated that a Si-Quat Antimicrobial Protectant with the active ingredient 3-(trimethoxysilyl) propyldimethyloctadecyl ammonium chloride eradicates SARS-CoV-2 (the unique coronavirus that causes COVID-19) on surfaces and provides continuous residual viricidal activity for more than six weeks.

The tests were conducted in both “wet” and “dry” conditions.  In the wet test, SARS-CoV-2 was coated on stainless steel disks which were then treated with a wet solution of the product with the active ingredient 3-(trimethoxysilyl) propyldimethyloctadecyl ammonium chloride formulation. In the dry test, the formulation was first applied to stainless steel samples which, 46 days later, were then exposed to a high titer of SARS-CoV-2.  Proving the longevity of the formulation on treated surfaces, tests revealed that the presence of the 3-(trimethoxysilyl) propyldimethyloctadecyl ammonium chloride formulation maintained the ability to inactivate SARS-CoV-2 to negligible levels.  Furthermore, test results from Rega demonstrated that the disks pretreated with the formulation averaged a 99.7% inactivation of the SARS-CoV-2 virus.  All tests conducted were designed to conform with the United States Environmental Protection Agency (EPA) and equivalent standards of regulatory agencies in Europe and Australia, to ensure the acceptability and credibility of the results.

Below is the EPA label of the Si-Quat Antimicrobial Protectant with the active ingredient 3-(trimethoxysilyl) propyldimethyloctadecyl ammonium chloride product (Si-Quat) that was used in the test.


https://www3.epa.gov/pesticides/chem_search/ppls/087583-00003-20170523.pdf

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The Silane Quaternary Ammonium Chloride (Si-Quat) compound is licensed to manufacturers who then private label the product to a variety of companies. The chemistry/structure of the Si-Quat is the same or very similar since the manufacturers are using the licensed 3-(trimethoxysilyl) propyldimethyloctadecyl ammonium chloride compound. The variance one will find between products is typically the concentration level of the Si-Quat active ingredient.

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  CLICK HERE for a comparison chart of four popular Si-Quat products.

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 Below is a video explaining how the Si-Quat compound works.